Parkinsons Disease Essay -- Disorders Illnesses Papers

Parkinsons maladyIn 1817, James Parkinson publish his famous treatise An Essay on the Shaking Palsy, describing the symptoms which now collectively obtain his name. Although many scientists before his time had described various aspects of motor disfunction (ataxia, paralysis, tremor) Parkinson was the first to collect them into a common syndrome one which he believed create a distinctive condition. His sixty-six page essay contained five chapters describing symptoms, derivative diagnoses, causality, possible treatments, and prospects for future study. What is most intriguing concerning Parkinsons analysis (besides its tenacious accuracy) is the fact that his clinical observations and inferences were made by watching the movements of six patriarchal males at a distance along the streets of London. The symptoms seen in Parkinsons unhealthiness (PD) ar of two distinct types (1) a degeneration of ruler actions and movements united with (2) the appearance of ab radiation patt ern-type behaviors. Positive symptoms are those behaviors not usually seen in normal people since they occur often in patients with PD, they are thought to be mechanistically inhibited by normal physiological systems. However, when these systems degenerate or become damaged, they are released and abnormal behavior is the result. The main abnormalities seen in Parkinsonian patients are resting tremor, muscular rigidity, and anesthesia. Resting tremors occur while the patient is motionless the symptoms disappear during application or when the patient is asleep. They most often encompass alternating movements of the limbs, custody and head for instance, one diagnostic tremor known as pill-rolling, consists of repetitious rolling motions of the forefinger past the... ... neurotoxin, 1-methyl--1,2,3,6-tetrahydro-pyridine. Life Science, 1985, 362503-2508. Neurochemistry. 1986, 46 1501-1507. 8. Schapira, A. H. V. et. al. Mitochondrial hard I deficiency in Parkinsons disease. J. of Neu rochemistry. 1990, 54 823-827. 9. Wachtel, H. Antiparkinsonian dopamine agonists a review of the pharmacokinetics and neuropharmacology in animals and humans. J. of Neural Transmission. 1991, 3 151-201. 10. Mercuri, N. B. et. al. Physiology and pharmacology of dopamine D2-receptors their implications in dopamine--substitute therapy for Parkinsons disease. Neurology. 1989, 391106-1108. 11. Riederer, P. Konradi, C. Youdim, M. B. H. The role of MAO in dopaminergic transmission. pp. 149-153. In M. B. Streifler, ed. Advances in Neurology, Vol. 53 Parkinsons disorder Anatomy, Pathology, and Therapy. New York, Raven Press, 1990. Parkinsons Disease Essay -- Disorders Illnesses PapersParkinsons DiseaseIn 1817, James Parkinson publish his famous treatise An Essay on the Shaking Palsy, describing the symptoms which now collectively knuckle under his name. Although many scientists before his time had described various aspects of motor disfunction (ataxia, paralysis, tremor) Parkinson was the first to collect them into a common syndrome one which he believed organize a distinctive condition. His sixty-six page essay contained five chapters describing symptoms, derivative diagnoses, causality, possible treatments, and prospects for future study. What is most intriguing concerning Parkinsons analysis (besides its consistent accuracy) is the fact that his clinical observations and inferences were made by watching the movements of six patriarchal males at a distance along the streets of London. The symptoms seen in Parkinsons Disease (PD) are of two distinct types (1) a degeneration of normal actions and movements linked with (2) the appearance of abnormal-type behaviors. Positive symptoms are those behaviors not usually seen in normal people since they occur often in patients with PD, they are thought to be mechanistically inhibited by normal physiological systems. However, when these systems degenerate or become damaged, they are released and abnormal behavior is the result. The main abnormalities seen in Parkinsonian patients are resting tremor, muscular rigidity, and anesthesia. Resting tremors occur while the patient is motionless the symptoms disappear during legal action or when the patient is asleep. They most often encompass alternating movements of the limbs, pass and head for instance, one diagnostic tremor known as pill-rolling, consists of repetitive rolling motions of the forefinger past the... ... neurotoxin, 1-methyl--1,2,3,6-tetrahydro-pyridine. Life Science, 1985, 362503-2508. Neurochemistry. 1986, 46 1501-1507. 8. Schapira, A. H. V. et. al. Mitochondrial compound I deficiency in Parkinsons disease. J. of Neurochemistry. 1990, 54 823-827. 9. Wachtel, H. Antiparkinsonian dopamine agonists a review of the pharmacokinetics and neuropharmacology in animals and humans. J. of Neural Transmission. 1991, 3 151-201. 10. Mercuri, N. B. et. al. Physiology and pharmacology of dopamine D2-receptors their implications in dopamine--substitute therapy for Parkinsons disease. Neurology. 1989, 391106-1108. 11. Riederer, P. Konradi, C. Youdim, M. B. H. The role of MAO in dopaminergic transmission. pp. 149-153. In M. B. Streifler, ed. Advances in Neurology, Vol. 53 Parkinsons Disease Anatomy, Pathology, and Therapy. New York, Raven Press, 1990.